Agmatine Sulfate: The Hot Natural Supplement

The more positive health benefits we discover about the natural compound agmatine, the more nutraceutical enthusiasts are hyped about using this supplement in their daily regimen. Agmatine is a natural compound derived from the amino acid arginine. It is found in humans, plants, animals, and bacteria and has many benefits when taken as the supplement “agmatine sulfate.” What sets this compound apart from others is that it can cross the Blood-Brain Barrier (BBB). This is important because only lipid-soluble molecules with light molecular weight can often cross the BBB, making agmatine a novel supplement1.

The History of Agmatine

In 1910 biochemist Albert Kossel discovered a naturally created substance from the amino acid arginine, now known as the supplement agmatine sulfate. This unique supplement works with our neurotransmitter systems, significantly impacting our brain health.

In 1955 it was discovered that agmatine displayed neuroprotective attributes. Because of this, agmatine has been used to treat:

  • Neuropathic pain.
  • Depression
  • Stroke
  • Epilepsy
  • Traumatic Brain Injury.
  • Mental Health Disorders (Depression and Anxiety).
  • Neurodegenerative Disorders2.
  • And Many Other Conditions…

Agmatine sulfate can be taken in powder or capsule form and is effective in treating many neurological conditions and is used widely as a pre-workout enhancer.

Agmatine Sulfate’s Use to Treat Types of Neuropathies

Neuropathy is a type of damage to our nervous system and can result in many symptoms such as:

  • Pain
  • Swelling
  • Numbness in the hands and feet.
  • Tingling
  • Weakness of the muscles.
  • Weakness in other areas of the body3.

It can be frustrating for those suffering from neuropathic pain because of its resistance to current medications. Studies have shown that using an oral supplement of agmatine sulfate, taken for at least three weeks, has proven to be more effective than other medicinal treatments for neuropathy.

Agmatine Sulfate As A Pre-Workout Booster

Agmatine sulfate is an ingredient you will find on many labels of powdered pre-workout supplements. Our bodies naturally produce Agmatine Sulfate, but because this compound is stored in the neurons of our brain taking agmatine sulfate pre-workout may help with:

  • Focus
  • Athletic Performance
  • Cognition
  • Mood

If you are like many of us, finding the motivation to work out can be difficult. Adding an agmatine sulfate supplement may help you stay on a committed workout regimen that will lead to a healthier lifestyle4.

How Does It Work?

A process in the body known as decarboxylation converts agmatine to arginine. This process extracts carboxylic acid from arginine. Why is this important? In the food and beverage industry, carboxylic acid is regularly used as a flavoring. While working out, agmatine sulfate prolongs nitric oxide in the body.2 It blocks synthase that breaks down nitric oxide, which gives you the following benefits during your workout:

  • Increase in Energy.
  • Short-term Pain Relief.
  • Supports Healthy Blood Pressure.
  • Reduces stress.
  • Reduces Cortisol.
  • Creates an Environment for Muscle Growth4.

Agmatine Sulfate Taken for Anxiety & Depression

In many of our lives where multi-tasking is inevitable, unavoidable stress wreaks havoc on our bodies. Many of us are left with the question: “how do I reduce stress in my life?” Chronic stress is highly detrimental to every area of our health. Chronic stress can lead to depression and anxiety disorders if not assessed and treated. Since agmatine sulfate works with the neurotransmitters in our brain, it has produced many positive effects involving our hippocampus and central nervous system.

The hippocampus is a densely packed layer of neurons found deep within our temporal lobe. Studies have shown that agmatine sulfate can have anti-depressive-like qualities due to its interaction with this complex part of our brain that plays a role in psychiatric disorders. These positive effects can lead to the reduction of stress-induced anxiety and depression5.

A Promising Outlook For a Complex Supplement

Many studies have been conducted with this naturally occurring supplement, one of which lasted up to 5 years and displayed no adverse side effects. One should always discuss adding any supplement to your daily regimen with your physician, mainly if you are prescribed other medications for the symptoms mentioned above.

Scientists believe we only understand 10 percent of our brain. That being said, with a supplement that works directly with the neurotransmitters in our brain, the possibilities are endless once more research and evidence are conducted on the brain and the infinite interactions it may have with dietary supplements.

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*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.*


  1. Agmatine,
  2. Long-Term Dosage of Dietary Agmatine,
  3. Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies,,with%20conventional%20neuropathic%20pain%20medications.
  4. 7 Big Agmatine Sulfate Benefits + Pre-Workout Boosting Power,
  5. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviors, and cognitive impairment by modulating the nitrergic signaling pathway,
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